Pub. Date : 2017 Mar
PMID : 28184939
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-17A promotes esophageal adenocarcinoma cell invasiveness through ROS-dependent, NF-kappaB-mediated MMP-2/9 activation. | Reactive Oxygen Species | interleukin 17A | Homo sapiens |
| 2 | Furthermore, IL-17A treatment significantly upregulated the expression of MMP-2 and MMP-9, stimulated intracellular ROS production, increased IkappaB-alpha phosphorylation and NF-kappaB nuclear translocation. | Reactive Oxygen Species | interleukin 17A | Homo sapiens |
| 3 | Nevertheless, IL-17A-induced expression of MMP-2/9 and OE19 cell invasiveness were both inhibited by pretreatment with N-acetyl-L-cysteine (NAC, a ROS scavenger) or pyrrolidine dithiocarbamate (PDTC, a NF-kappaB inhibitor). | Reactive Oxygen Species | interleukin 17A | Homo sapiens |
| 4 | In conclusion, these findings demonstrate that IL-17A can promote the migration and invasiveness of EAC cells through ROS/NF-kappaB/MMP-2/9 signaling pathway activation, indicating that IL-17A may be a potential therapeutic target for EAC. | Reactive Oxygen Species | interleukin 17A | Homo sapiens |
| 5 | In conclusion, these findings demonstrate that IL-17A can promote the migration and invasiveness of EAC cells through ROS/NF-kappaB/MMP-2/9 signaling pathway activation, indicating that IL-17A may be a potential therapeutic target for EAC. | Reactive Oxygen Species | interleukin 17A | Homo sapiens |