Pub. Date : 2017
PMID : 28182780
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FTS pretreatment significantly enhanced DHA/ARS-induced phosphatidylserine (PS) externalization, Bak/Bax activation, mitochondrial membrane depolarization, cytochrome c release, and caspase-8 and -9 activations, characteristics of the extrinsic and intrinsic apoptosis. | farnesylthiosalicylic acid | caspase 8 | Homo sapiens |
| 2 | Pretreatment with Z-IETD-FMK (caspase-8 inhibitor) potently prevented the cytotoxicity of the combination treatment of DHA/ARS and FTS, and pretreatment with Z-VAD-FMK (pan-caspase inhibitor) significantly inhibited the loss of DeltaPsim induced by DHA/ARS treatment or the combination treatment of DHA/ARS and FTS in HCC cells. | farnesylthiosalicylic acid | caspase 8 | Homo sapiens |