Title : HMGB1-TLR4 Axis Plays a Regulatory Role in the Pathogenesis of Mesial Temporal Lobe Epilepsy in Immature Rat Model and Children via the p38MAPK Signaling Pathway.

Pub. Date : 2017 Apr

PMID : 28176142






1 Functional Relationships(s)
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1 Pre-treatment with p38MAPK inhibitor SB203580 decreased the levels of TNF-alpha and IL-1beta, while downregulation of TLR4 significantly reduced HMGB1-induced p38MAPK signaling pathway activation. SB 203580 tumor necrosis factor Homo sapiens