Title : Mathematical modelling unveils the essential role of cellular phosphatases in the inhibition of RAF-MEK-ERK signalling by sorafenib in hepatocellular carcinoma cells.

Pub. Date : 2017 Apr 28

PMID : 28161506






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1 Mathematical modelling unveils the essential role of cellular phosphatases in the inhibition of RAF-MEK-ERK signalling by sorafenib in hepatocellular carcinoma cells. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens
2 Sorafenib, the medical treatment of reference against advanced stages of hepatocellular carcinoma (HCC), inhibits the RAF-MEK-ERK cascade in HCC cells. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens
3 We analysed the dynamic regulation of the core components of the RAF-MEK-ERK cascade in three human HCC cell lines (Huh7, Hep3B and PLC/PRF5) with heterogeneous responses to sorafenib. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens
4 These findings highlight an unexpected mode of action of sorafenib on the kinome of HCC cells, and open new perspectives regarding the therapeutic targeting of the RAF-MEK-ERK cascade in this context. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens