Pub. Date : 2017 Jun
PMID : 28159772
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS AND RESULTS: Using genome-wide gene expression analysis in a mouse model of ventilator-induced lung injury, we discovered a previously unsuspected mechanism by which CO2 can protect against injury: induction of the transporter protein for alpha-tocopherol, alpha-tocopherol transfer protein (alphaTTP). | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | tocopherol (alpha) transfer protein | Mus musculus |
| 2 | Pulmonary alphaTTP was induced by inspired CO2 in two in vivo murine models of ventilator-induced lung injury; the level of alphaTTP expression correlated with degree of lung protection; and, absence of the alphaTTP gene significantly reduced the protective effects of CO2. | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | tocopherol (alpha) transfer protein | Mus musculus |
| 3 | Pulmonary alphaTTP was induced by inspired CO2 in two in vivo murine models of ventilator-induced lung injury; the level of alphaTTP expression correlated with degree of lung protection; and, absence of the alphaTTP gene significantly reduced the protective effects of CO2. | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | tocopherol (alpha) transfer protein | Mus musculus |
| 4 | CONCLUSIONS: Inspired CO2 upregulates alphaTTP which increases lung alpha-tocopherol levels and inhibits synthesis of a pathogenic chemoattractant. | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | tocopherol (alpha) transfer protein | Mus musculus |