Pub. Date : 2017 Oct 10
PMID : 28158949
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MsrA gene deletion exacerbated cisplatin-induced reductions in the expression and activity of MsrA and MsrBs, and the expression of thioredoxin 1, glutathione peroxidase 1 and 4, mitochondrial superoxide dismutase, cystathionine-beta-synthase, and cystathionine-gamma-lyase. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 2 | MsrA gene deletion exacerbated cisplatin-induced reductions in the expression and activity of MsrA and MsrBs, and the expression of thioredoxin 1, glutathione peroxidase 1 and 4, mitochondrial superoxide dismutase, cystathionine-beta-synthase, and cystathionine-gamma-lyase. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 3 | Cisplatin induced swelling, cristae loss, and fragmentation of mitochondria with increased lipid peroxidation, more so in MsrA-/- than in MsrA+/+ kidneys. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 4 | Cisplatin induced swelling, cristae loss, and fragmentation of mitochondria with increased lipid peroxidation, more so in MsrA-/- than in MsrA+/+ kidneys. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 5 | MsrA deletion exacerbated cisplatin-induced increases in Bax to Bcl-2 ratio, cleaved caspase-3 level, and apoptosis, whereas MsrA overexpression attenuated cisplatin-induced oxidative stress and apoptosis. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 6 | MsrA deletion exacerbated cisplatin-induced increases in Bax to Bcl-2 ratio, cleaved caspase-3 level, and apoptosis, whereas MsrA overexpression attenuated cisplatin-induced oxidative stress and apoptosis. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 7 | MsrA deletion exacerbated cisplatin-induced increases in Bax to Bcl-2 ratio, cleaved caspase-3 level, and apoptosis, whereas MsrA overexpression attenuated cisplatin-induced oxidative stress and apoptosis. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 8 | INNOVATION: MsrA gene deletion in mice exacerbates cisplatin-induced renal injury through increases of mitochondrial susceptibility, whereas MsrA overexpression protects cells against cisplatin. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 9 | INNOVATION: MsrA gene deletion in mice exacerbates cisplatin-induced renal injury through increases of mitochondrial susceptibility, whereas MsrA overexpression protects cells against cisplatin. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 10 | CONCLUSION: This study demonstrates that MsrA protects kidney cells against cisplatin-induced methionine oxidation, oxidative stress, mitochondrial damage, and apoptosis, suggesting that MsrA could be a useful target protein for the treatment of cisplatin-induced nephrotoxicity. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 11 | CONCLUSION: This study demonstrates that MsrA protects kidney cells against cisplatin-induced methionine oxidation, oxidative stress, mitochondrial damage, and apoptosis, suggesting that MsrA could be a useful target protein for the treatment of cisplatin-induced nephrotoxicity. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 12 | CONCLUSION: This study demonstrates that MsrA protects kidney cells against cisplatin-induced methionine oxidation, oxidative stress, mitochondrial damage, and apoptosis, suggesting that MsrA could be a useful target protein for the treatment of cisplatin-induced nephrotoxicity. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |
| 13 | CONCLUSION: This study demonstrates that MsrA protects kidney cells against cisplatin-induced methionine oxidation, oxidative stress, mitochondrial damage, and apoptosis, suggesting that MsrA could be a useful target protein for the treatment of cisplatin-induced nephrotoxicity. | Cisplatin | methionine sulfoxide reductase A | Mus musculus |