Pub. Date : 2017 Apr
PMID : 28157137
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extracellular polyamines-induced proliferation and migration of cancer cells by ODC, SSAT, and Akt1-mediated pathway. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 2 | Polyamines upregulated the expression of ornithine decarboxylase (ODC), SSAT, Akt1, Akt, hypoxia-inducible factors-1alpha, vascular endothelial growth factor, and matrix metalloproteinases, and downregulated p27 expression. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 3 | In Akt1-overexpression cells, polyamines also upregulated the expression of ODC, SSAT, hypoxia-inducible factors-1alpha, vascular endothelial growth factor, and matrix metalloproteinases and downregulated p27 expression. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 4 | In conclusion, extracellular polyamines induced proliferation and cancer cell migration by inducing ODC and SSAT expression, and the Akt1-mediated pathway. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |