Title : CYP2B6 Genotype Guided Dosing of Propofol Anesthesia in the Elderly based on Nonparametric Population Pharmacokinetic Modeling and Simulations.

Pub. Date : 2017

PMID : 28154789






4 Functional Relationships(s)
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1 CYP2B6 Genotype Guided Dosing of Propofol Anesthesia in the Elderly based on Nonparametric Population Pharmacokinetic Modeling and Simulations. Propofol cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 Model-based dosing-simulations comparing patients with the CYP2B6 AA & AG genotypes to both GG genotypes and patients from a multicenter trial suggest a 50% decrease in propofol infusion dose, to 25mg/kg/min, be made to result in approximately equivalent drug exposures. Propofol cytochrome P450 family 2 subfamily B member 6 Homo sapiens
3 CONCLUSION: Based on the pharmacometric modeling and simulation, if no dosage adjustments are made for the elderly CYP2B6 AA and AG genotypes, a 250% higher propofol blood exposure will be evident within 1-hour from the start of the infusion. Propofol cytochrome P450 family 2 subfamily B member 6 Homo sapiens
4 Thus, based on the pharmacokinetic model, genotyping elderly patients for the CYP2B6 AA and AG gene variants will decrease the total propofol blood exposure during anesthesia and sedation when an infusion dose adjustment is made to 25mg/kg/min. Propofol cytochrome P450 family 2 subfamily B member 6 Homo sapiens