Pub. Date : 2017 Feb 1
PMID : 28145471
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic effects of metformin with liraglutide against endothelial dysfunction through GLP-1 receptor and PKA signalling pathway. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 2 | Metformin upregulated GLP-1 receptor (GLP-1R) level and protein kinase A (PKA) phosphorylation. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 3 | Metformin upregulated GLP-1 receptor (GLP-1R) level and protein kinase A (PKA) phosphorylation. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 4 | Furthermore, AMPK inhibitor compound C abolished the metformin-mediated upregulation of GLP-1R level and PKA phosphorylation. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 5 | Moreover, metformin stimulates GLP-1R and PKA signalling via AMPK-dependent pathway, which may account for its synergistic protective effects with liraglutide. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |