Title : Contribution of remote substrate binding energy to the enzymatic rate acceleration for 3α-hydroxysteroid dehydrogenase/carbonyl reductase.

Pub. Date : 2017 Oct 1

PMID : 28137513






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH with the rate limiting step being the release of NADH. NAD aldo-keto reductase family 1 member C4 Homo sapiens
2 3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH with the rate limiting step being the release of NADH. NAD aldo-keto reductase family 1 member C4 Homo sapiens
3 3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH with the rate limiting step being the release of NADH. NAD aldo-keto reductase family 1 member C4 Homo sapiens
4 The rate limiting step is hydride transfer for 3alpha-HSD/CR catalyzing the reaction of cyclohexanol with NAD+ based on the observed rapid equilibrium ordered mechanism and equal deuterium isotope effects of 3.9 on V and V/K for cyclohexanol. NAD aldo-keto reductase family 1 member C4 Homo sapiens