Pub. Date : 2017 May
PMID : 28130399
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In chronic lymphocytic leukemia (CLL), STAT3 is constitutively phosphorylated on serine 727 and plays a role in the pathobiology of CLL. | Serine | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Mass spectrometry was used to identify casein kinase 2 (CK2), a serine/threonine kinase that coimmunoprecipitated with serine phosphorylated STAT3 (pSTAT3). | Serine | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Furthermore, activated CK2 incubated with recombinant STAT3 induced phosphorylation of STAT3 on serine 727. | Serine | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Furthermore, activated CK2 incubated with recombinant STAT3 induced phosphorylation of STAT3 on serine 727. | Serine | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | Finally, confocal microscopy determined that CD5 is cell membrane bound, and fractionation studies revealed that the CK2/CD5/BLNK/STAT3 complex remains in the cytoplasm, whereas serine pSTAT3 is shuttled to the nucleus.Implications: These data show that the cellular proteins CK2, CD5, and BLNK are required for constitutive phosphorylation of STAT3 in CLL. | Serine | signal transducer and activator of transcription 3 | Homo sapiens |