Title : Metallo-Toehold-Activated Catalytic Hairpin Assembly Formation of Three-Way DNAzyme Junctions for Amplified Fluorescent Detection of Hg2.

Pub. Date : 2017 Feb 22

PMID : 28117978






2 Functional Relationships(s)
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1 On the basis of the substantial signal amplification by metallo-toehold-triggered, catalytic hairpin assembly (CHA) formation of three-way DNAzyme junctions, we have constructed a highly selective and sensitive fluorescent sensing system for the determination of Hg2+ in different environmental water samples. Water polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens
2 The developed sensing method offers high selectivity toward the target Hg2+ over other possible competing metal ions due to the specific T-Hg2+-T bridge structure chemistry in the metallo-toehold domain, and reliable detection of spiked Hg2+ in environmentally relevant water samples with this method is also verified. Water polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens