Title : Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation.

Pub. Date : 2017 Jan 19

PMID : 28103884






1 Functional Relationships(s)
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1 Mechanistically, Induction of AhR/CYP1A1 by TCDD and DMBA was associated with significant increase in beta-Catenin mRNA and protein expression, nuclear translocation and its downstream target Cyclin D1, whereas AhR or CYP1A1 knockdown using shRNA dramatically inhibited beta-Catenin cellular content and nuclear translocation. Polychlorinated Dibenzodioxins cyclin D1 Homo sapiens