Title : Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Pub. Date : 2017 Feb 7

PMID : 28096356






1 Functional Relationships(s)
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1 Here, we provide evidence that MLKL-induced activation of NLRP3 requires (i) the death effector four-helical bundle of MLKL, (ii) oligomerization and association of MLKL with cellular membranes, and (iii) a reduction in intracellular potassium concentration. Potassium NLR family pyrin domain containing 3 Homo sapiens