Pub. Date : 2017 Apr 1
PMID : 28087840
18 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate cytotoxicity of Cholix on human hepatocytes in the presence of tumor necrosis factor alpha (TNF-alpha), which has been reported to play a fatal role in PEA administered to mice. | cholix | tumor necrosis factor | Homo sapiens |
| 2 | In this study, we demonstrate cytotoxicity of Cholix on human hepatocytes in the presence of tumor necrosis factor alpha (TNF-alpha), which has been reported to play a fatal role in PEA administered to mice. | cholix | tumor necrosis factor | Homo sapiens |
| 3 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 4 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 5 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 6 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 7 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 8 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 9 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 10 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 11 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 12 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 13 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 14 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 15 | Compared with incubating HepG2 cells with Cholix alone, co-treatment with TNF-alpha and Cholix (TNF-alpha/Cholix) significantly enhanced the activation of caspases, cytochrome c release from mitochondria into cytoplasm, and poly-ADP-ribose polymerase (PARP) cleavage, while incubation with TNF-alpha alone or co-treatment with TNF-alpha/catalytically inactive Cholix did not. | cholix | tumor necrosis factor | Homo sapiens |
| 16 | In the early stage of cell death, Cholix increased phosphorylation of mitogen-activated protein kinases (e.g., p38, ERK, JNK) and Akt, which was not affected by TNF-alpha alone. | cholix | tumor necrosis factor | Homo sapiens |
| 17 | Reactive oxygen species (ROS) inhibitor, N-acetyl cysteine (NAC), suppressed TNF-alpha/Cholix-induced JNK and ERK phosphorylation, resulting in inhibition of PARP cleavage. | cholix | tumor necrosis factor | Homo sapiens |
| 18 | These data suggest that ROS and JNK pathways are important mediators of TNF-alpha/Cholix-induced HepG2 cell death. | cholix | tumor necrosis factor | Homo sapiens |