Title : NF-κB Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance.

Pub. Date : 2017 Feb 24

PMID : 28082672






1 Functional Relationships(s)
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1 We show here that in both squamous cell carcinoma cells and melanoma tumor cells, CQ induced NF-kappaB activation and the expression of its target genes HIF-1alpha, IL-8, BCL-2, and BCL-XL through the accumulation of autophagosomes, p62, and JNK signaling. Chloroquine C-X-C motif chemokine ligand 8 Homo sapiens