Title : FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.

Pub. Date : 2017 Apr

PMID : 28082351






1 Functional Relationships(s)
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Protein Name
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1 Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused by mutations in NPC1 or NPC2 with decreased functions leading to lysosomal accumulation of cholesterol and sphingolipids. Cholesterol NPC intracellular cholesterol transporter 2 Homo sapiens