Title : Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export.

Pub. Date : 2017 Feb 14

PMID : 28069952






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The toxic proline:arginine (PRn) poly-dipeptide encoded by the (GGGGCC)n repeat expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the central channel of the nuclear pore and inhibits the movement of macromolecules into and out of the nucleus. Arginine C9orf72-SMCR8 complex subunit Homo sapiens