Title : Antibiotic tigecycline enhances cisplatin activity against human hepatocellular carcinoma through inducing mitochondrial dysfunction and oxidative damage.

Pub. Date : 2017 Jan 29

PMID : 28069382






1 Functional Relationships(s)
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1 Mechanistically, tigecycline specifically inhibits mitochondrial translation as shown by the decreased protein levels of Cox-1 and -2 but not Cox-4 or Grp78, and increased mRNA levels of Cox-1 and -2 but not Cox-4 in HCC cells exposed to tigecycline. Tigecycline heat shock protein family A (Hsp70) member 5 Homo sapiens