Title : Amelioration of apelin-13 in chronic normobaric hypoxia-induced anxiety-like behavior is associated with an inhibition of NF-κB in the hippocampus.

Pub. Date : 2017 Apr

PMID : 28065733






3 Functional Relationships(s)
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1 We found that CNH treatment decreased APJ but increased Iba-1 proteins expression, as well as nucleus translocation of p50 and p65 in the hippocampus, which were reversed by apelin-13 treatment. 1-hydroxy-11-norcadinan-5-en-4-one apelin Mus musculus
2 In addition, apelin-13 treatment ameliorated CNH-induced anxiety-like behavior in mice, suggesting anxiogenic effect of apelin-13 might be mediated by an inhibition of NF-kappaB activation in microglial of the hippocampus. 1-hydroxy-11-norcadinan-5-en-4-one apelin Mus musculus
3 Furthermore, apelin-13 treatment reversed p-CAMKII decrease in the hippocampus under CNH treatment. 1-hydroxy-11-norcadinan-5-en-4-one apelin Mus musculus