Pub. Date : 2017 Mar 7
PMID : 28060750
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation. | Doxorubicin | homeodomain interacting protein kinase 2 | Homo sapiens |
| 2 | HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation. | Doxorubicin | homeodomain interacting protein kinase 2 | Homo sapiens |
| 3 | Next, we assessed cell response following UV-irradiation or treatment with doxorubicin, two well-known HIPK2 activators, by evaluating cell number and viability, p53-Ser46 phosphorylation, p21 induction, and caspase cleavage. | Doxorubicin | homeodomain interacting protein kinase 2 | Homo sapiens |
| 4 | Interestingly, cells expressing HIPK2-T566P mutant did not respond to UV-irradiation, while behaved similarly to wt HIPK2 upon doxorubicin-treatment. | Doxorubicin | homeodomain interacting protein kinase 2 | Homo sapiens |
| 5 | Evaluation of HIPK2-T566 phosphorylation status by a T566-phospho-specific antibody showed constitutive phosphorylation in unstressed cells, which was maintained after doxorubicin-treatment but inhibited by UV-irradiation. | Doxorubicin | homeodomain interacting protein kinase 2 | Homo sapiens |