Title : Mitotic catastrophe and cell cycle arrest are alternative cell death pathways executed by bortezomib in rituximab resistant B-cell lymphoma cells.

Pub. Date : 2017 Feb 21

PMID : 28055975






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 BTZ stabilized p21, CDC2, and cyclin B in RRCL and in primary tumor cells. Bortezomib H3 histone pseudogene 16 Homo sapiens
2 Transient p21 knockdown alleviates BTZ-induced senescence inhibition, G2-M cell cycle blockade, and mitotic catastrophe. Bortezomib H3 histone pseudogene 16 Homo sapiens
3 Our data suggest that BTZ can induce apoptosis or mitotic catastrophe and that p21 has a pivotal role in BTZ activity against RRCL. Bortezomib H3 histone pseudogene 16 Homo sapiens