Pub. Date : 2017 Jan 5
PMID : 28054591
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 2 | The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 3 | The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 4 | The proinflammatory cytokine interleukin 1beta (IL-1beta) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 5 | In the presence of MAPK inhibitors, IL-1beta-induced COX-2 expression and PGE2 release were both attenuated. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 6 | These observations suggest that JNK1 phosphorylation is necessary for the activation of the MEK/ERK1/2 pathway and the subsequent COX-2 expression for PGE2 release, and p38 independently contributes to the IL-1beta effect in synovial fibroblasts. | Dinoprostone | interleukin 1 beta | Homo sapiens |