Title : Application of Static Modeling --in the Prediction of In Vivo Drug-Drug Interactions between Rivaroxaban and Antiarrhythmic Agents Based on In Vitro Inhibition Studies.

Pub. Date : 2017 Mar

PMID : 28053220






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Amiodarone, dronedarone, and their major metabolites, N-desethylamiodarone (NDEA) and N-desbutyldronedarone (NDBD), demonstrate inhibitory effects on CYP3A4 and CYP2J2 with U.S. Food and Drug Administration-recommended probe substrates. Dronedarone cytochrome P450 family 2 subfamily J member 2 Homo sapiens
2 In this study, in vitro inhibition assays using rivaroxaban as the probe substrate demonstrated that both dronedarone and NDBD produced reversible inhibition as well as irreversible mechanism-based inactivation of CYP3A4- and CYP2J2-mediated metabolism of rivaroxaban. Dronedarone cytochrome P450 family 2 subfamily J member 2 Homo sapiens