Pub. Date : 2017 Feb 7
PMID : 28052039
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced mesangial cell proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 2 | Furthermore, inhibiting mPGES-1 by a siRNA approach in MCs also ameliorated UA-induced MC proliferation in line with a significant blockade of PGE2 secretion. | Dinoprostone | prostaglandin E synthase | Mus musculus |
| 3 | In conclusion, our findings indicated that COX-2/mPGES-1/PGE2 cascade activation mediated UA-induced MC proliferation. | Dinoprostone | prostaglandin E synthase | Mus musculus |