Title : Interleukin 3 enhanced interleukin 2-dependent maturation of NK progenitor cells in bone marrow from mice with severe combined immunodeficiency.

Pub. Date : 1989 Nov

PMID : 2805072






3 Functional Relationships(s)
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1 Importantly, IL 3 could induce the generation of NK activity from 5-FU-treated marrow cells in the presence of IL 2. Fluorouracil interleukin 3 Mus musculus
2 Kinetic studies indicated that NK activity was appreciably generated from 5-FU-treated marrow cells when preincubated with IL 3 at least for 12 hr and subsequently cultured with IL 2. Fluorouracil interleukin 3 Mus musculus
3 The cells bearing IL 2 receptors appeared in 5-FU-treated marrow cells, even though cultured only with IL 3, which implied that IL 3 could support the development of very primitive NK cells from IL 2-unresponsive to IL 2-responsive states. Fluorouracil interleukin 3 Mus musculus