Title : Substrates and Inhibitors of SAMHD1.

Pub. Date : 2017

PMID : 28046007






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this paper, we evaluated the impact of 2" sugar moiety substitution for different nucleotides on being substrates for SAMHD1 and mechanisms of actions for the results. Sugars SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens
2 Our computational modeling suggests that (2"S)-2"-methyl sugar moiety clashing with the Y374 of SAMHD1. Sugars SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens