Pub. Date : 2017 Mar
PMID : 28039934
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 promotes hepatic bile acid synthesis by an E prostanoid receptor 3-mediated hepatocyte nuclear receptor 4alpha/cholesterol 7alpha-hydroxylase pathway in mice. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 2 | CONCLUSION: Our results demonstrated an unexpected role of proinflammatory mediator PGE2 in improving hepatic cholesterol metabolism through activation of the EP3-mediated PKA/HNF4alpha/CYP7A1 pathway, indicating that inhibition of this pathway may be a novel therapeutic strategy for dyslipidemia and atherosclerosis. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |