Title : Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer.

Pub. Date : 2017 Feb 7

PMID : 28038470






4 Functional Relationships(s)
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1 Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1alpha regulator, we hypothesized that PHD2 and EGFR may be interconnected at the molecular level. Oxygen egl-9 family hypoxia inducible factor 1 Homo sapiens
2 Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1alpha regulator, we hypothesized that PHD2 and EGFR may be interconnected at the molecular level. Oxygen egl-9 family hypoxia inducible factor 1 Homo sapiens
3 Since the oxygen sensor hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is considered to be the main HIF-1alpha regulator, we hypothesized that PHD2 and EGFR may be interconnected at the molecular level. Oxygen egl-9 family hypoxia inducible factor 1 Homo sapiens
4 Overall, we introduce for the first time the direct crosstalk between the oxygen sensor PHD2 and EGFR-mediated tumorigenesis in breast cancer. Oxygen egl-9 family hypoxia inducible factor 1 Homo sapiens