Title : Synthesis of new pyrazolo[3,4-d]pyrimidine derivatives and evaluation of their anti-inflammatory and anticancer activities.

Pub. Date : 2017 Jul

PMID : 28032452






1 Functional Relationships(s)
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1 In addition, six of these compounds (7b, 10a-d, and 12c) demonstrated inhibition of LPS-induced COX-2 protein expression at low concentration (25 mug/ml) as compared to the control non-stimulated cells and showed a COX-2 selectivity index range comparable to diclofenac sodium. Diclofenac cytochrome c oxidase II, mitochondrial Rattus norvegicus