Pub. Date : 2017 Mar
PMID : 28030368
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ORMDL3 is one of three ORMDL proteins that integrate multiple signals to maintain sphingolipid homeostasis. | Sphingolipids | ORMDL sphingolipid biosynthesis regulator 3 | Homo sapiens |
| 2 | Universal overexpression of ORMDL3 decreases serum sphingolipids, increases inflammatory markers, airway remodeling and AHR in response to allergic stimuli. | Sphingolipids | ORMDL sphingolipid biosynthesis regulator 3 | Homo sapiens |
| 3 | ORMDL3 might have a critical role for smooth muscle contraction.Little is known about how the different ORMDL3 single nucleotide polymorphisms affect human blood and tissue sphingolipid profiles. | Sphingolipids | ORMDL sphingolipid biosynthesis regulator 3 | Homo sapiens |
| 4 | ORMDL3 might have a critical role for smooth muscle contraction.Little is known about how the different ORMDL3 single nucleotide polymorphisms affect human blood and tissue sphingolipid profiles. | Sphingolipids | ORMDL sphingolipid biosynthesis regulator 3 | Homo sapiens |
| 5 | SUMMARY: Possible mechanisms how ORMDL3 affects asthma include inhibition of sphingolipid synthesis, synergistic effects with known allergens and a combination of both. | Sphingolipids | ORMDL sphingolipid biosynthesis regulator 3 | Homo sapiens |