Title : Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes.

Pub. Date : 2017 Jan 15

PMID : 28011195






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1 In this study, using direct co-culture model with LPS-activated and Dox-induced senescent THP-1 monocytes, we reported for the first time ROS-induced DNA damage, reduced metabolic activity, proliferation inhibition and cell cycle arrest followed by p16-, p21- and p27-mediated DNA damage response pathways activation, premature senescence and apoptosis induction in HeLa cells. Doxorubicin zinc ribbon domain containing 2 Homo sapiens