Pub. Date : 2017 Apr 1
PMID : 28003439
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our previous in vitro study showed that volatile anesthetic isoflurane directly inhibits leukocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1), critical adhesion molecules on leukocytes. | Isoflurane | integrin alpha L | Mus musculus |
| 2 | Our previous in vitro study showed that volatile anesthetic isoflurane directly inhibits leukocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1), critical adhesion molecules on leukocytes. | Isoflurane | integrin alpha L | Mus musculus |
| 3 | Thus, the role of isoflurane exposure on in vivo LFA-1 and Mac-1 function was examined using polymicrobial abdominal sepsis model in mice. | Isoflurane | integrin alpha L | Mus musculus |
| 4 | Isoflurane impaired neutrophil recruitment to the abdominal cavity by inhibiting LFA-1 function. | Isoflurane | integrin alpha L | Mus musculus |
| 5 | In conclusion, prolonged isoflurane exposure worsened the outcome of experimental polymicrobial abdominal sepsis and was associated with impaired neutrophil recruitment and bacterial phagocytosis via reduced LFA-1 and Mac-1 function. | Isoflurane | integrin alpha L | Mus musculus |