Title : SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

Pub. Date : 2017 Feb

PMID : 27991919






2 Functional Relationships(s)
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1 Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells. Nucleosides SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens
2 Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells. Nucleosides SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens