Title : Kvβ1.1 (AKR6A8) senses pyridine nucleotide changes in the mouse heart and modulates cardiac electrical activity.

Pub. Date : 2017 Mar 1

PMID : 27986658






1 Functional Relationships(s)
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1 In vivo, isoproterenol infusion led to increased NADH in the heart along with QTc prolongation in wild-type mice; regardless of the approach, our data show that Kvbeta1.1 recognizes NADH changes and modulates Kv4.2 currents affecting AP and QTc durations. qtc potassium voltage-gated channel, shaker-related subfamily, beta member 1 Mus musculus