Title : Potent inhibition of human organic cation transporter 2 (hOCT2) by β-carboline alkaloids.

Pub. Date : 2017 Dec

PMID : 27977936






3 Functional Relationships(s)
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1 All tested beta-carbolines potently inhibited hOCT2 with IC50 values in the sub- or low micromolar range. Carbolines solute carrier family 22 member 2 Homo sapiens
2 Importantly, the potent inhibition of hOCT2 by beta-carbolines also raises the concern of potential drug interactions between naturally occurring bioactive alkaloids and drugs eliminated by hOCT2. Carbolines solute carrier family 22 member 2 Homo sapiens
3 Importantly, the potent inhibition of hOCT2 by beta-carbolines also raises the concern of potential drug interactions between naturally occurring bioactive alkaloids and drugs eliminated by hOCT2. Carbolines solute carrier family 22 member 2 Homo sapiens