Title : Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species.

Pub. Date : 2017 Apr

PMID : 27975234






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Following activation by NQO1, IB-DNQ participates in a catalytic futile reduction/reoxidation cycle with consequent toxic reactive oxygen species generation within the tumor microenvironment. Reactive Oxygen Species NAD(P)H quinone dehydrogenase 1 Homo sapiens