Title : Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.

Pub. Date : 2017 Jan 20

PMID : 27959508






2 Functional Relationships(s)
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1 In the current study, a structure-based approach has been applied to a Grp94 nonselective compound, SNX 2112, which led to the development of 8j (ACO1), a Grp94-selective inhibitor that manifests ~440 nM affinity and >200-fold selectivity against cytosolic Hsp90 isoforms. 8j heat shock protein 90 beta family member 1 Homo sapiens
2 In the current study, a structure-based approach has been applied to a Grp94 nonselective compound, SNX 2112, which led to the development of 8j (ACO1), a Grp94-selective inhibitor that manifests ~440 nM affinity and >200-fold selectivity against cytosolic Hsp90 isoforms. 8j heat shock protein 90 beta family member 1 Homo sapiens