Pub. Date : 2014 Feb 1
PMID : 27919042
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fibroblast-to-myofibroblast switch is mediated by NAD(P)H oxidase generated reactive oxygen species. | Reactive Oxygen Species | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |
| 2 | This report demonstrates two novel aspects of the TGFbeta1 signalling cascade, namely the generation of ROS due to a biphasic NAD(P)H oxidase activity and a ROS-dependent downstream activation of p38 leading to a transition of dermal fibroblasts to MFs that can be inhibited by the selective NAD(P)H oxidase inhibitor apocynin. | Reactive Oxygen Species | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |