Title : Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile.

Pub. Date : 2017 Jan 15

PMID : 27916468






1 Functional Relationships(s)
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1 Four compounds; diphenylthiazole glycine derivatives (15a, 15b) and diphenylimidazolo acetic acid derivatives (19a, 19b), which possess carboxylic acid group exhibited significant activity and selectivity against COX-1 over COX-2. Carboxylic Acids mitochondrially encoded cytochrome c oxidase II Homo sapiens