Title : Knockdown of Inhibitory Guanine Nucleotide Binding Protein Giα-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats.

Pub. Date : 2016 Oct 26

PMID : 27912212






1 Functional Relationships(s)
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1 Furthermore, Gialpha-2 and Gialpha-3 antisense oligodeoxynucleotide treatments significantly decreased the enhanced levels of Gialpha-2 and Gialpha-3 proteins, respectively, and enhanced levels of superoxide anion and NADPH oxidase activity in heart, aorta, and kidney and hyperproliferation of vascular smooth muscle cells from SHRs aged 6 weeks. Superoxides G protein subunit alpha i3 Rattus norvegicus