Title : R59949, a diacylglycerol kinase inhibitor, inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells.

Pub. Date : 2017 Feb

PMID : 27909743






3 Functional Relationships(s)
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1 Stimulation of RASMCs with IL-1beta caused a marked increase in transplasmalemmal L-arginine uptake into RASMCs. Arginine interleukin 1 beta Rattus norvegicus
2 L-Arginine uptake in the presence of IL-1beta was markedly inhibited by R59949, while basal L-arginine uptake was not significantly affected by R59949. Arginine interleukin 1 beta Rattus norvegicus
3 Both IL-1beta-induced NO production and L-arginine uptake were abolished in the presence of cycloheximide (1 muM). Arginine interleukin 1 beta Rattus norvegicus