Pub. Date : 2016 Nov 28
PMID : 27892502
2 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | We used skeletal muscle-specific Cpt1b knockout mouse model where the inhibition of mitochondrial fatty acid oxidation results in accumulation of lipid metabolites in muscle and elevated circulating free fatty acids. | Fatty Acids | carnitine palmitoyltransferase 1b, muscle | Mus musculus | ||
| 2 | We show that the inflammatory response elicited by elevated intracellular lipids in skeletal muscle is repressed in Cpt1bm-/- mice, strongly supporting the hypothesis that mitochondrial processing of fatty acids is essential for the lipid-induction of inflammation in muscle. | Fatty Acids | carnitine palmitoyltransferase 1b, muscle | Mus musculus | ||