Pub. Date : 2016
PMID : 27871084
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis. | olmesartan | sirtuin 1 | Mus musculus |
| 2 | Moreover, olmesartan restored silent mating type information regulation 1 (SIRT1) expression in diabetic glomeruli. | olmesartan | sirtuin 1 | Mus musculus |
| 3 | Moreover, olmesartan restored silent mating type information regulation 1 (SIRT1) expression in diabetic glomeruli. | olmesartan | sirtuin 1 | Mus musculus |
| 4 | In vitro study revealed that olmesartan prevented angiotensin II/p38/SIRT1 induced podocyte apoptosis, but it only slightly prevented high glucose/AMPK/SIRT1 induced podocyte apoptosis. | olmesartan | sirtuin 1 | Mus musculus |
| 5 | CONCLUSIONS: Olmesartan reduced albuminuria in diabetic nephropathy through inhibiting angiotensin II/p38/SIRT1 triggered podocyte apoptosis. | olmesartan | sirtuin 1 | Mus musculus |