Title : Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy.

Pub. Date : 2017 Jan 3

PMID : 27869649






2 Functional Relationships(s)
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1 Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis. calcipotriene thymic stromal lymphopoietin Homo sapiens
2 Importantly, calcipotriol plus 5-FU treatment induced TSLP, HLA class II, and natural killer cell group 2D (NKG2D) ligand expression in the lesional keratinocytes associated with a marked CD4+ T cell infiltration, which peaked on days 10-11 after treatment, without pain, crusting, or ulceration. calcipotriene thymic stromal lymphopoietin Homo sapiens