Title : Direct in vivo evidence on the mechanism by which nanoparticles facilitate the absorption of a water insoluble, P-gp substrate.

Pub. Date : 2016 Nov 30

PMID : 27863655






1 Functional Relationships(s)
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1 In conclusion, mucoadhesive, drug solubilising GCPh nanoparticles enable the oral absorption of paclitaxel via the saturation of the P-gp pump (by high local drug concentrations) and by particle uptake and tight junction opening mechanisms. Paclitaxel phosphoglycolate phosphatase Homo sapiens