Pub. Date : 2017 Mar
PMID : 27862873
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS: To investigate, in the Carotid Atherosclerosis: Metformin for Insulin Resistance (CAMERA) trial (NCT00723307), whether the influence of metformin on the glucagon-like peptide (GLP)-1 axis in individuals with and without type 2 diabetes (T2DM) is sustained and related to changes in glycaemia or weight, and to investigate basal and post-meal GLP-1 levels in patients with T2DM in the cross-sectional Diabetes Research on Patient Stratification (DIRECT) study. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 2 | Using 6-monthly fasted total GLP-1 levels over 18 months, we evaluated metformin"s effect on total GLP-1 with repeated-measures analysis and analysis of covariance. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 3 | RESULTS: In CAMERA, metformin increased total GLP-1 at 6 (+20.7%, 95% confidence interval [CI] 4.7-39.0), 12 (+26.7%, 95% CI 10.3-45.6) and 18 months (+18.7%, 95% CI 3.8-35.7), an overall increase of 23.4% (95% CI 11.2-36.9; P < .0001) vs placebo. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 4 | In the DIRECT study, metformin was associated with higher fasting active (39.1%, 95% CI 21.3-56.4) and total GLP-1 (14.1%, 95% CI 1.2-25.9) but not post-meal incremental GLP-1. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 5 | In the DIRECT study, metformin was associated with higher fasting active (39.1%, 95% CI 21.3-56.4) and total GLP-1 (14.1%, 95% CI 1.2-25.9) but not post-meal incremental GLP-1. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 6 | CONCLUSIONS: In people without diabetes, metformin increases total GLP-1 in a sustained manner and independently of changes in weight or glycaemia. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |
| 7 | Metformin-treated patients with T2DM also have higher fasted GLP-1 levels, independently of weight and glycaemia. | Metformin | glucagon like peptide 1 receptor | Homo sapiens |