Title : Sensitivity of TP53-Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity.

Pub. Date : 2017 Oct

PMID : 27861885






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 TP53-depeleted LNCaP and NCI-H460 cells using shRNA targeting human TP53 were more sensitive to cell death by treatment of genistein. Genistein tumor protein p53 Homo sapiens
2 TP53-depeleted LNCaP and NCI-H460 cells using shRNA targeting human TP53 were more sensitive to cell death by treatment of genistein. Genistein tumor protein p53 Homo sapiens
3 These data suggest that genistein may be a promising anticancer drug candidate due to its inhibitory activity against Plk1 as well as EGFR and effectiveness toward cancer cells, especially those with p53-mutation. Genistein tumor protein p53 Homo sapiens