Title : Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice.

Pub. Date : 2017 Feb 1

PMID : 27852737






4 Functional Relationships(s)
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1 Water-restricted, wild-type mice showed an increase in vasopressin and aldose reductase mRNA, sorbitol, fructose and uric acid in the supraoptic nucleus. Water arginine vasopressin Homo sapiens
2 With water restriction, vasopressin in the pituitary of wild-type mice was significantly less than that of fructokinase-knockout mice, indicating that fructokinase-driven vasopressin secretion overrode synthesis. Water arginine vasopressin Homo sapiens
3 NEW & NOTEWORTHY: This study increases our understanding of the mechanisms leading to vasopressin release under conditions of water restriction (acute dehydration). Water arginine vasopressin Homo sapiens
4 Nevertheless, mice undergoing water restriction remain capable of maintaining sufficient vasopressin (copeptin) levels to allow normal urinary concentration. Water arginine vasopressin Homo sapiens