Pub. Date : 2017 Feb
PMID : 27837675
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer"s disease. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 2 | We provide evidence that although PGE2 had no effect both on either basal transmission or short-term plasticity, it strongly impaired presynaptic Mf-CA3 long-term potentiation (LTP) by acting on PGE2 receptor 3 (EP3) receptors. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 3 | During aging, hippocampal levels of PGE2 markedly increased in the APP/PS1 mouse model of AD and impaired specifically presynaptic LTP via a PGE2-EP3 signaling pathway. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 4 | During aging, hippocampal levels of PGE2 markedly increased in the APP/PS1 mouse model of AD and impaired specifically presynaptic LTP via a PGE2-EP3 signaling pathway. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |
| 5 | In summary, the building up of PGE2 during the progression of AD leads to specific impairment of hippocampal presynaptic plasticity and highlights EP3 receptors as a potential target to alleviate cognitive deficits in AD. | Dinoprostone | prostaglandin E receptor 3 (subtype EP3) | Mus musculus |