Title : PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease.

Pub. Date : 2017 Feb

PMID : 27837675






5 Functional Relationships(s)
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1 PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer"s disease. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus
2 We provide evidence that although PGE2 had no effect both on either basal transmission or short-term plasticity, it strongly impaired presynaptic Mf-CA3 long-term potentiation (LTP) by acting on PGE2 receptor 3 (EP3) receptors. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus
3 During aging, hippocampal levels of PGE2 markedly increased in the APP/PS1 mouse model of AD and impaired specifically presynaptic LTP via a PGE2-EP3 signaling pathway. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus
4 During aging, hippocampal levels of PGE2 markedly increased in the APP/PS1 mouse model of AD and impaired specifically presynaptic LTP via a PGE2-EP3 signaling pathway. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus
5 In summary, the building up of PGE2 during the progression of AD leads to specific impairment of hippocampal presynaptic plasticity and highlights EP3 receptors as a potential target to alleviate cognitive deficits in AD. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus